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VERTIGO AND PSYCHOLOGICAL DISTURBANCES

Timothy C. Hain, MD Page last modified: May 13, 2017

Introduction.chicken and egg

Psychological problems are related to vertigo in a complex way. They may both be a cause as well as a consequence of dizziness (Staab and Ruckenstein, 2003).

We are not talking about chronic vertigo -- As Clark pointed out (2001), "The patient with chronic dizziness should never be labeled with psychogenic dizziness. Chronic does not mean psychogenic. Chronic means that health care has been unsuccessful" .

Psychological abnormalities in dizzy patients -- and keeping them in a reasonable perspective

Psychological abnormalities are common in the general population, even more common in those who are ill, and are certainly also common in individuals with vertigo. Many studies suggest that about 50% of persons who present to clinics for dizziness have psychological disorder, mainly anxiety. Studies of patients with dizziness also suggests that they mainly have reactive anxiety and depression (Savastano et al, 2007). A review of the prevalence of panic was published by Simon and others (1998). They document prevalance varying from 3 to 41%, in dizziness specialty clinic. Of this table, our experience matches best the findings of Clark et al (20%).

It should be realized that psychological testing (unlike MRI scans, or even clinical examinations by neurologists) cannot diagnose "organic" disorders of the brain or neurochemistry. Questionnaires are subjective -- people can say whatever they please, irregardless of the state of their brain. Accordingly, in our opinion at least, these sorts of tests are not "diagnostic" of a disease, but rather are "descriptive" of a particular mental state, subscribed to at the time that the questionnaire was administered.

In our opinion, shared by Savastino et al (2007), the most likely explanation for these sorts of lists are reactive psychological disturbances, rather than primary psychiatric problems. This differs modestly from the conclusions of Staab et al (2003), a psychiatrist, who in considering a study of 132 undiagnosed or "psychogenic" patients, concluded that there were three groups of roughly equal size -- reactive psychiatric disturbances, primary psychiatric disturbances, and a mixture of both. We suspect that the difference in opinion has to do with sampling bias, and a tendency to diagnose what one knows best.

Models for associations between psychiatriac disorders and vestibular dysfunction.

Simon and associates (1998) reviewed three explanatory models (hypotheses) regarding the known association between anxiety (panic) and dizziness.

I. Non-localized vertigo

At present there is no reliable method of consistently distinguishing among patients with dizziness caused by a psychiatric condition, nonlocalized dizziness, and the dizziness accompanied by a psychiatric condition. Thus, discussions of psychogenic dizziness are characterized by considerable opinion and a paucity of objective evidence. The biggest problem in evaluation of these patients is separating psychogenic from nonlocalized vertigo. Accordingly we will first discuss various types of nonlocalized vertigo, and then proceed to talk about psychogenic vertigo specifically.

IA. Non-localized vertigo in the acute care setting

We define nonlocalized dizziness vertigo as the situation where there is reasonable probability that the patient has a structural disorder of the brain or inner ear, but there no objective evidence to substantiate this hypothesis. Diagnoses often assigned to patients in acute care settings include: Unknown or nonspecific (acute) vertigo, Labyrinthitis, Post traumatic vertigo, "Vasovagal" syncope, and Hyperventilation syndrome. The "unknown or nonspecific" vertigo diagnosis is often appropriate in the acute setting. For example, one might see a patient in the ER (Emergency Room) with dizziness, note that routine ER labs (CBC, electrolytes, CT scan of head) are normal, and find no nystagmus, ataxia or otologic disturbance. One might reasonably in this case simply indicate that the diagnosis is unclear, coding the patient as "Vertigo", and either wait for the symptoms to remit spontaneously, or initiate a more detailed evaluation.

The labyrinthitis diagnosis as well as vestibular neuritis diagnosis is encountered mainly in emergency room settings, Strictly speaking, the diagnosis of labyrinthitis cannot be well substantiated in a non-localized patient as nystagmus and hearing complaints are required for a well-substantiated diagnosis. Patients typically present with dizziness, nausea and/or vomiting, and otherwise resemble patients with "unknown/nonspecific vertigo". Post traumatic vertigo is a nonlocalized vertigo that follows a significant head injury. Localizable diagnoses encountered in this setting, roughly in order of frequency, include benign paroxysmal positional vertigo, labyrinthine concussion, post-traumatic migraine, cervical vertigo, perilymph fistula, temporal bone fracture, and epileptic vertigo. Frequently these specific diagnoses are not made in the acute setting.

Vasovagal syncope is a diagnosis that is ordinarily based entirely on history, and in which there are no physical findings at the time of examination. Postural hypotension should be ruled out.

Hyperventilation syndrome requires more discussion and can be divided into three categories: 1) Persons with "normal" lightheadedness from hyperventilation, 2) Persons with structural ear or CNS disorders that are reactive to hyperventilation such as MS, and vestibular nerve injuries 3) Persons with panic/anxiety states who may hyperventilate inappropriately and are abnormally reactive to hyperventilation.

In a classic study, Drachman and Hart (1972) evaluated 100 patients in a neurotology setting. Their protocol included two minutes of hyperventilation. In persons who had no physical findings, and became dizzy after this procedure, a diagnosis of "hyperventilation syndrome" was assigned. Roughly 30% of their patients were diagnosed as having hyperventilation syndrome. However, subsequent studies of large numbers of dizzy patients (e.g. Nedzelski, 1986), have failed to report such a large proportion of patients with hyperventilation syndrome. So, this hyperventilation induced dizziness is a controversial diagnosis. In our opinion, there are relatively few patients with hyperventilation syndrome. The two minute hyperventilation protocol of Drachman and Hart is overly sensitive, and instead we advocate one minute of hyperventilation. Hyperventilation sensitivity is nonspecific and a positive hyperventilation test does not exclude the presence of a vestibular or CNS lesions. Management consists of a combination of reassurance and small doses of benzodiazepines.

Summary: diagnosis of nonlocalized vertigo in the acute care situation is intrinsically difficult and often inaccurate.

IB. NONLOCALIZED VERTIGO IN AMBULATORY (NON-ACUTE CARE) SETTINGS

Entities often assigned to patients in ambulatory settings are Unknown or nonspecific (chronic) vertigo, Disequilibrium of the elderly, Vertebrobasilar insufficiency, Vestibular Meniere's disease, and Unknown or Nonspecific Vertigo: These patients are generally those who have had intermittent or persistent dizziness or vertigo for several weeks or more, have a normal physical examination, and normal ENG, audiometry, and MRI. Many of these patients may have undocumented organic vestibular lesions. At present, we have no clinical tests that can identify lesions of the vertical semicircular canals or otolith organs or, for that matter, exclude lesions. For example, we encountered a case of a woman, presenting with vertigo, who had had a herpes zoster infection of the seventh and eighth nerve on one side, a year prior to examination. Caloric testing documented complete loss of lateral canal function on the side of lesion. Examination demonstrated a classic BPPV type nystagmus on the side of lesion, clearly documenting that posterior canal function remained in spite of a history and test pattern suggesting complete loss of function.

Disequilibrium of the Elderly: In elderly patients, it is unusual for the physician to say that he does not know what is causing dizziness. Instead, dizziness and/or ataxia without localizing signs are often designated as "disequilibrium of the elderly", and attributed to the ravages of age. For example, in a series of 740 patients with dizziness, Belal and Glorig (1986) reported that 79% were given the diagnosis of "presbyastasis," a term synonymous with disequilibrium of aging. According to the authors, this diagnosis was assigned to persons above the age of 65 in whom no specific cause of dizziness was identified. In a recent study, 116 elderly patients presenting to a highly subspecialized Neurotology setting were examined. After a thorough assessment, about 20% of patients were diagnosed as "Undetermined" and "vestibulopathy, undetermined"; about 10% were diagnosed as psychophysiologic (Baloh et al, 1989).

Should dizziness in elderly persons without a localizable lesion be attributed solely to aging? Most elderly do show some measurable sensory or central nervous system differences from younger people. However, a potential source of error is to attribute ataxia or dizziness to lesions that are not causally connected. For example, there are many patients with small infarction, minor sensory dysfunction, cataracts, etc., which by themselves would not be enough to cause ataxia, but which, possibly in combination, may be responsible for ataxia in the elderly. Moreover, how do we know that an arbitrary combination of sensory, central, and motor deficits is an adequate explanation for ataxia?

In the elderly, there is a special problem because of our unwillingness to subject patients to extensive diagnostic evaluations. For example, Fife and Baloh (1993) recently pointed out the high prevalence of bilateral vestibulopathy in elderly patients who had disequilibrium or dizziness of uncertain cause. This diagnosis usually requires rotatory chair testing, a test which is often difficult to obtain. The approach to the management of dizziness of nonlocalized cause in the elderly should be cautious and empirical. These patients usually need to be followed more closely than patients in whom a clear diagnosis is available. As in the younger population, empirical trials of medication, psychiatric consultation, and physical therapy may be helpful.

Vertebrobasilar TIA is a diagnosis that is often assigned to patients with nonlocalized vertigo who have multiple vascular risk factors (Grad and Baloh, 1989). When there are clear transient central nervous system symptoms and signs, the diagnosis can be made with confidence. However, in most instances, this is not the case and one must retain a healthy skepticism.

Vestibular Meniere's is a diagnosis mainly made by Otologists. It usually denotes episodic vertigo without otologic symptoms, with normal audiometry and MRI. This diagnosis should not be used to describe all vertigo of unknown cause. It should be used for patients whose symptoms suggest endolymphatic hydrops without hearing loss.

Overview: Diagnosis of nonlocalized vertigo in the ambulatory setting is ordinarily tentative and cautious.

II. Psychological Syndromes that can cause dizziness (Psychogenic Vertigo)

Psychogenic dizziness or vertigo consists of a sensation of motion (spinning, rocking, tilting, levitating etc.) that can be reasonably attributed to a psychiatric disorder (e.g. anxiety, depression, somatization disorder).

Psychogenic dizziness is a subcategory of a larger group of patients, including roughly 15% of dizzy patients, who have a normal examination and laboratory evaluations.

Psychogenic dizziness is distinct from other members of the group which include dizziness accompanied by a psychiatric condition (such as benign positional vertigo accompanied by a reactive phobia or anxiety), and also from nonlocalized dizziness that has no clear objective correlate (such as dizziness caused by a condition that cannot be detected by current diagnostic technology).

According to Dietrich and Staab (2016), "functional dizziness" is the "new term" for somatoform or psychogenic dizziness. Why do we need a new term ?

Panic Syndrome

Anxiety and Panic: These are troubling diagnoses to make in dizzy patients, because there is an intrinsic ambiguity in causality -- between the chicken and egg -- are dizzy patients afraid of getting hurt, or are patients just so "worked up" that they are dizzy.

When someone has a dizzy spell driving down the road, and then becomes anxious when they drive down the road -- is the problem the anxiety or is it it the dizziness ?

A situational pattern (e.g. dizziness that disappears on vacation) is the major factor that helps in making the diagnosis of anxiety causing dizziness. Other symptoms suggestive of anxiety disorder such as a lump in the throat (globus) may also be helpful. To us, this seems to be more of a way of saying how strong the anxiety might be, rather than shedding any light on the cause of the distress.

Psychometric testing may sometimes exclude these diagnoses, as persons without anxiety are unlikely to have dizziness related to anxiety. However, because many patients with dizziness are justifiably anxious, psychometric testing rarely makes any causal diagnosis. The diagnostic criteria for panic unfortunately define a syndrome that may be impossible to separate from episodic vertigo, accompanied by a reactive anxiety.

Patients with panic by DSM III criteria often have abnormal vestibular tests (Jacob et al, 1989) and patients with dizziness often meet criteria for panic (Clark et al, 1994).

Somatization Syndrome

The criteria for somatization syndrome requires between four and six unexplained symptoms, excluding dizziness. The problem is that otherwise unexplained nausea, headache, or fatigue might be caused by a vestibular imbalance, and accordingly studies reporting high incidence of somatization syndrome in dizzy patients must be looked upon with considerable suspicion.

I could, for example, define a "syndrome" consisting of a basket of symptoms -- but what would that really mean ?

As such, in dizzy patients, somatization syndrome is usually a "wastebasket" diagnosis. Management is entirely psychiatric.

Depression

While modest symptoms of depression are more common in dizzy patients(Ketola et al, 2007), patients will also point out that having an undiagnosed disabling illness can be accompanied by depression. In our experience, most depression is reactive rather than primary. The major exception occurs when dizziness symptoms are used by depressed patients who are attempting to make a contact with the medical system, hoping to obtain treatment without being labeled as having a socially stigmatizing psychiatric disorder. Of the antidepressants, tricyclics with a substantial anticholinergic component (e.g. amitriptyline) are best chosen for those patients in whom there is a suspicion of mixed organic/psychiatric disturbance or migraine. The SSRI family (Prozac, Zoloft, etc.), are reasonable choices where one thinks that depression is primary. Recall that the SSRI family often cause nausea as a side effect and also that Prozac has an inordinately long half life. Venlafaxine is a good choice when there aspects that resemble migraine.

Malingering.

Dizziness is largely subjective and thus it can be simulated in an attempt to obtain compensation. The literature suggests that seeking compensation is often a factor in persons with mild head trauma (Binder et al, 1996). Paniak et al (2002), noted that compensation seekers/recievers report symptom incidence and severity as approximately 1 standard deviation higher than persons who were not seeking or receiving financial compensation.

Astute clinicians, armed with sufficient tools to detect nystagmus, can nearly always detect malingering of dizziness. There are also many laboratory methods of detecting malingering of dizziness or malingering of hearing.

In our opinion, patients who have spent perhaps a few hours on the web reading about dizziness, are very arrogant to think that they can successfuly fool a clinician who has several decades of experience with dizzy patients. A discussion concerning how one can detect malingering for the bilateral loss type dizziness can be found here.

 

III. PSYCHOLOGICAL SYNDROMES THAT MAY BE A CONSEQUENCE OF VERTIGO

Slowed reactions and problems with "multitasking" (see brainfog page for more)

Many individuals with vestibular disorders complain of trouble thinking. Most commonly people say that they can't "multitask". Recent work has suggested that this difficult thinking is measurable and significant. Redfern and others recently documented that reaction times are longer in patients with unilateral vestibular loss than normal controls (2003). This effect increases when patients are attempting to balance. Normal subjects also exhibit longer reaction times when responding to postural perturbations. This appears to be due to a diversion of attention to postural demands, leaving less available for cognitive processing of other input (Redfern et al, 2002).

Sometimes stimulants are helpful. Of course, stimulants may make anxiety worse, and may be addictive too, so their use should be judicious.

Anxiety and Depression

It is well recognized that anxiety may accompany vertigo (Pollak et al, 2003).

Formal studies suggest a very high prevalance of anxiety in persons with inner ear disorders (e.g. between 25 and 50%). (Best et al, 2009). Anxiety could be a natural and logical consequence of a medical condition that is associated with unsteadiness and loss of control of bodily functions. Persons with Menieres' disease, for example, have reactive anxiety and depression (Savastino et al, 2007). Similarly, persons with migraine or other severe headaches are much more likely to be depressed (3X) than persons without major painful illnesses (Breslau et al, 2000). This is not very surprising.

Having considerable anxiety provoked by a medical illness does not seem to us to be a disease, but rather a personality style. Nevertheless, the clinician seeking to improve the lot of his/her patients needs to be able to recognize reasonable and appropriate anxiety and separate it from unreasonable, counterproductive anxiety. All benzodiazepine medications (those in the "valium" family) reduce balance in otherwise normal persons. However, they may improve balance in persons with inner ear or central disturbances.

Similarly, depression is a natural reaction to loss. When depression becomes so severe that it impairs other aspects of ones life, then treatment for depression itself is reasonable. As all antidepressants impair balance to some extent, one should be cautious, and again, seek to take just the "right dose".

Diagnoses of Exclusion -- wastebasket syndromes

We presently have four different acronyms for "I don't know why you are dizzy". Generally speaking, one would not attribute symptoms of headache to a psychological cause, if one knew that there was a large brain tumor. In other words, many psychiatric disorders are explanations offered for symptoms that lack an "organic explanation".

This situation causes ambiguity to arise between the "lack of organic diagnosis" label, or the "its all in your head". In one case, the health care indicates that the problem is intractable. In the other, the health care provider indicates that a cause for symptoms HAS been identified, and it is in the category of mental illness.

Many of us prefer not to say that we can't figure something out, and one method of doing this, is to make up a word to substitute for the "I can't figure it out" diagnosis, that sounds as if it is figured out. In our opinion, PPV, CSD, and now PPPD are examples of these.

It seems unlikely that we need all of these terms.

Phobic postural vertigo (PPV)

Brandt (1991) described a symptom complex that he termed "phobic postural vertigo" characterized by situationally triggered panic attacks, frequently including vertigo with unsteadiness. PPV differs slightly from CSD (below) in that it is triggered rather than constant. The diagnostic criteria for PPV (see below) consist of symptoms without physical signs (Holmberg et al, 2009).

Using Brandt's words to be sure we identify what he is talking about:

Holberg et al suggested that persons with phobic postural vertigo might be more sensitive to proprioceptive disturbances than healthy subjects and also refrain from use of vision (2003). In essence then, they are suggesting that PPV might be a "somatosensory dependence" syndrome. As other authors suggest that phobic vertigo is typified by visual dependence, it seems that there is a conflict in definitions.

PPV is mainly reported in the Eastern European literature (i.e. in Germany). It is not a popular diagnosis in the USA. We suspect that in other parts of the world, the same symptoms are called something else -- such as "I don't know why you are dizzy". We wish that an acronym that wasn't so easily confused with BPPV had been chosen.

Chronic Subjective Dizziness (CSD) also known as PPPD (see below).

Staab and Ruckenstein (2007) outlined a new acronym for unexplained dizziness -- "CSD" for Chronic Subjective Dizziness. They stated:

"Chronic subjective dizziness is a specific clinical syndrome with the cardinal feature of persistent nonspecific dizziness that cannot be explained by active medical conditions. It is not a diagnosis of exclusion".

To our way of thinking, if it "cannot be explained by active medical conditions", it is a "diagnosis of exclusion". Active medical conditions are excluded. In other words, the the definition of this entity is problematic.

Paraphrasing their criteria, from their paper in 2007, CSD is dizziness that has these features:

These are broad criteria. In other words, in our opinion, someone diagnosed with "CSD" is being told by their doctor that they don't know why they are dizzy. It primarily differs from PPV, in that PPV is defined as being episodic and triggered.

Again, we remind the reader of what Clark pointed out (2001),

"The patient with chronic dizziness should never be labeled with psychogenic dizziness. Chronic does not mean psychogenic. Chronic means that health care has been unsuccessful" .

Here Clark is pointing out the logical difference between "lack of proof", and "proof of lack".

Persistent postural-perceptual dizziness (PPPD).

PPPD is the replacement acronym for CSD -- chronic subjective dizziness (Thompson, Goetting, Staab and Shepard; 2015). Bittar et al (2015) defined PPPD as "dizziness that lasts for over three months with no clinical explanation for its persistence." The full acronym is "Persistent postural perceptual dizziness". PPPD, or "triple-P D".

According to Dietrich and Staab's 2016 review, "Functional dizziness is the new term for somatoform or psychogenic dizziness".

Post-traumatic stress syndrome (PTSD)

Some attacks of vertigo are so psychologically stressing that they may cause psychological disorders (usually panic or anxiety). These are particularly common in accidental situations -- someone who became dizzy, as a consequence of an injury, may be reluctant to ever again expose themselves to the same environment. PTSD, like other psychiatric diagnoses, is a judgement call. There is no MRI, blood test, CT scan, electrical study that can diagnose PTSD. It is defined by a committee.

Agoraphobia and acrophobia

Agoraphobia, dread of being in or crossing open places, is usually considered a "functional" -- psychogenic, cause of dizziness. Height phobia, or acrophobia often accompanies agoraphobia.

Agoraphobia and acrophobia, however, might be a logical reactions to dizziness rather than a cause, as agoraphobia is a reasonable adaptation to a condition that affects balance in an unpredictable way. Open places neither have surfaces that can be used for support nor close visual referents. Certainly, agoraphobia may also have psychic mechanisms. This determination as well as treatment are best made by a psychiatric professional, after you have made a reasonable search for an organic disorder.

These disorders are generally treated by desensitization. Virtual reality is presently being explored as a treatment. (Coelho et al, 2009)

Space and Motion Discomfort (SMD)

This term has been used by the University of Pittsburgh group to describe individuals with agoraphobia, acrophobia, and visual vertigo (Jacob et al, 2009). The term has not been adopted by most others who work with dizzy patients, and we see no particular reason to use it instead of the root terms themselves.

Visual vertigo

Some authors claim that exacerbation of dizziness and related symptoms by stimulating visual environments is typical of psychogenic vertigo (Staab and Ruckenstein, 2003. More can be found on this symptom under the heading of visual dependence. The difficulty of this assertion is that organic vertigo often results in sensitivity to visual environments. Another difficulty is that other authors claim the opposite, and that psychogenic vertigo is typified by increased dependence on somatosensory input (Holmberg et al, 2003).

In the author's opinion, these patterns reflect a sensory reweighting so that vestibular inputs are downweighted and replaced by greater dependence on anything else -- vision, somatosensory input, or internal estimates of bodily orientation and movement. They are not necessarily psychogenic, and in fact, usually are accompanied by an organic vestibular disturbance.

References

Copyright May 13, 2017 , Timothy C. Hain, M.D. All rights reserved. Last saved on May 13, 2017