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Osmophobia in Migraine

Timothy C. Hain, MD, Chicago IL. Page last modified: January 12, 2019

See also: sensory sensitivity in migraine light sensitivity pressure sensitivity sound sensitivity

Osmophobia means "abnormal sensitivity to smell". Perhaps more precisely, it is fear of smell. While sound sensitivity is divided up into a variety of subcategories -- for example, misophonia, hyperacusis, phonophobia, this doesn't seem to have been paid as much attention to with smell.

Osmophobia is an uncommon symptom with few causes.

There are many other senses and smell sensitivity is just one of many possibilities.

Sense Threshold Discomfort Measure Comment
Light Light sensitivity Photophobia    
Sound Hyperacusis Phonophobia LDL Correlates with smell sensitivity (Rocho-Filho et al, 2016)
Smell Smell sensitivity Osmophobia Upsit, Sniffit  
Weather Barosensitivity ? Barophobia ?    
Pain Allodynia      
Motion sensitivity kinesiophobia Motion sickness Various questionnaires Motion sickness can trigger smell sensitivity

Here we are going to mainly concentrate on migraine, but we will try to put it into context with other smell disorders.

Causes of smell sensitivity

Smell sensitivity is rare, and usually attributed to migraine or psychological conditions. However, sometimes it is reported in motion sickness, and presumably there is come cross-over with other sensory sensitivities that accompany other medical conditions (e.g. pregnancy, liver failure). Smell sensitivity also occurs in "multiple chemical sensitivity" (Alobid et al, 2014) According to Henkin et al, patients with Cystic fibrosis have lowered thresholds to taste and smell (1962).

Increased sensitivity to smell as well as other irritants may be a personality characteristic -- Bell et al (1994) suggested that "cacosmia" -- sensitivity to environmental chemical odors was associated with high ratings for stress in the first 4 decades of life, as well as increased prevalence of physician-diagnosed nasal allergies, breast cysts, hypothyroidism, sinusitis, food sensitivities, irritable bowel, and migraine headache. We suspect there is something to the idea that there are individuals who have a sensitive personality style.

Smell sensitivity ordinarily goes down with age. (Seow et al, 2016).

Measurement of smell sensitivity

The technology of measurement of measuring sensory hypersensitivity is probably best worked out for sound, where assessment of "LDL" or loudness discomfort levels are routine when fitting hearing aids.

One would think that for all of these situations, one should "adjust" the discomfort level for the threshold -- or in other words, attempt to differentiate between the input to the brain and the response to the brain. For hearing, this can be done by subtracting the pure tone threshold from the LDL. This simple concept does not seem to have penetrated into the literature about other senses.

As is the case with sound and light sensitivity, for measurement, there is an attempt to distinguish between having a lower threshold, and having greater discomfort. There are also instruments that identify substances that one can detect. This is called "discrimination". The UPSIT smell identification test is one way to assess -- this is a "scratch and sniff" technology type test. It costs about $30/patient to administer, so perhaps not the most appropriate method for a clinic. Another test that may be more cost effective is the "sniffin sticks". These are multiple use.

For smell in particular, thresholds vary with nasal congestion and age. Older people can't smell as well as younger people, and persons with clogged noses can't smell much of anything. Neurodegenerative disorders such as Alzheimer's disease or Parkinson's disease, may start with loss of sense of smell, many years before there is measurable cognitive decline. Interestingly, AD patients don't know that they can't smell, showing that subjective instruments cannot be relied upon. (Nordin et al, 1995)

Another consideration is that as is the case with light, sound, and other senses, during a migraine, smell may be more bothersome to migraine patients.

Demarquay et al (2006) used the term "hedonicity" for the pleasentness of smells, and reported that patients with olfactory hypersensitivity judged odors less pleasant, but of equal intencity. Saisu et al (2011) reported how "offensive" odors were to migraine patients, and noted that perfume, rose and Japanese cypress odors were more "offensive to migraine patients" than controls. One would naturally wonder if patients with migraine might be conditioned to dislike strong odors, because of the association with pain. In other words, perhaps this is a learned response.

 

Triggering of migraine with smells

Similarly to loud noise, motion, or strong light, strong smells have been reported to cause migraines.

Blau and Solomon (1985) reported that odors, pleasant or otherwise, could precipitate migraine in 11 out of 50 patients. Kelman reported that perfume or odor triggers migraine in about 50%.

Smell as a diagnostic criteria for migraine

The general consensus is that smell is very specific but insensitive. Here we are talking about the offensiveness of odors, not whether or not they can be detected.

Chalmer et al, in a "nosographic analysis of osmophobia" (ha ha), reported that roughly 1/3 of migraine patients report osmophobia, but only 1.2% of tension headache patients. (Chalmer et al, 2018). Chitsaz et al (2017) found that a much higher percentage of both migraine and tension headache patients (about 74% vs 43%) reported osmophobia.

Spiering's et al (2001) reported that weather, smell of smoke and light were precipitating factors that differentiated migraine from tension headache. Silva-Neto et al (2014) also suggested that osmophobia "may be a specific marker to differentiate migraine from tension-type headache". As both migraine and tension are artificial constructs based on meeting entirely subjective criteria, we are dubious that there is much significance to this observation other than the question set answer affirmatively by migraine patients seems to correlate with osmophobia as well.

Kelman (2004) reported that nearly half of 724 migraine patients reported perfume or odor triggers for migraines. This seems a bit high. Kelman reported again in 2004 that "Osmophobia and taste abnormalities were demonstrated to be very specific in diagnosing migraine IHS 1.1-1.6, but very insensitive." This seems more reasonable.

Zanchin et al (2005) again concluded that osmophobia is a very specific marker for migraine, separating it from other primary headaches and tension headaches.

Corletto et al (2008) again concluded that osmophobia is specific but insensitive.

De Carlo et al (2012) reported that osmophobia is "one of the major predictors for the development of migraine".

Wang et al (2012) suggest that osmophobia might be a preferable diagnostic criteria in asian migraineurs, among whom photophobia was less common.

Finally, some patients with migraine, as is the case as with light, may have an "olfactory aura". (Diamond et al, 1985; Coleman et al, 2011; Mainardi et al, 2016).

Intensity of smell perception in migraine subjects.

Drummond paper

Figure 2 from Snyder and Drummond (1997).

Snyder and Drummond (1997) compared 20 patients with migraine, mainly women, with 21 patients with fewer than 8 headaches per year. They found that patients with migraine or migraine with aura had slightly lower thresholds to vanillin than controls. The migraine patients did not find acetone more unpleasant than controls.

Hirsch (1992) reported that 18% of patients were low or unable to smell Pyridine. This is somewhat opposite to Synder and Drummond, but perhaps there is something special about Pyridine. Somewhat similarly, Marmura et al (2014) reported that about 25% of their 42 migraine attack subjects reported a drop in their sense of smell during attacks. Again, Whiting et al (2015) reported that migraine subjects were slieghtly less sensitive to the UPSIT test on both migraine and non-migraine days. Contrary to these observations, Harriott (2014) suggested that Migraineurs report sensitivity to odors during and between attacks (this is a vague statement), and also quoted the same paper as above (Snyder and Drummond) to suggest that acetone "is detected at lower concentrations in migraineurs who report osmosensitivity". Perhaps there are two groups of migraine patients - -those with smell sensitivity and those without ? This would fit into the general conjecture that "migraine" is not a single disorder. If we adopt this idea however, we need to do a lot more "splitting".

It would seem from these data that smell intensity ratings are unlikely to be useful for migraine diagnosis, but might be useful to separate out a subgroup.

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Copyright January 30, 2019 , Timothy C. Hain, M.D. All rights reserved. Last saved on January 30, 2019