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Occipital Neuralgia

Timothy C. Hain, MD Page last modified: March 20, 2017

You may also be interested in our many pages on migraine on this site

Occipital nerves
Occipital nerve Gray
Image from Origin of occipital nerves from View is from back of skull.

Occipital neuralgia is usually due to trauma to the occipital nerve (ON), often caused by an auto-accident where the head impacts the headrest. Other causes are spondylosis of the upper cervical spine (C1-C2), or rarely focal neuropathies due to diabetes or tumor (Ehni and Benner, 1984). Chiropractic manipulations of the neck are another potential source.

The occipital nerve may become entrapped beneath the attachments of the trapezius and semispinalis capitis muscles to the occipital bone (Loukas et al, 2006).

In occipital neuralgia, there are paroxysms of severe occipital pain, that often resemble severe migraines. The pain may be so severe that blood pressure rises to extreme levels. Some authors report eye pain from occipital neuralgia. (Mason et al, 2004), and even dental pain has been reported (Sulfaro et al, 1995). Experimental injections in humans of the greater occipital nerve cause severe pain in the trigeminal distribution (Piovesan et al, 2001).

Some patients with occipital neuralgia also have dizziness, presumably due to a variant of cervical vertigo. See our cervical vertigo page for more about this complicated subject.

Many patients with occipital neuralgia also experience typical migraine symptoms. This may be due to "convergence" of pain input triggering a common pathway of migraine. (Cady, 2007)

There are two branches to the occipital nerve -- the greater and lesser. Most of the time, the injury is to the greater ON.  The ON takes most of its origin from the C2 nerve root. Damage to the C2 nerve root, and possibly also the upper cord, can cause occipital neuralgia.

A comprehensive review of occipital neuralgia can be found in an article by Vanelderen et al. (2010).

Epidemiology of occipital neuralgia.

Occipital neuralgia is very uncommon, at least as compared to migraine. In our practice, as of the end of 2014, we had 30 patients diagnosed with occipital neuralgia, compared to nearly 3000 patients with migraine. Thus in our otoneurology practice, the ratio of ON to migraine is about 1:100. In our patients, females predominate (25/30), and the average age is 52. This is a similar distribution to our migraine patients.

There is a greater prevalence of litigation in patients with occipital neuralgia than in patients with most other conditions. This is because head or neck trauma is the usual mechanism of injury in occipital neuralgia.

Differential diagnosis of occipital neuralgia

For a person with severe tenderness just below their occiput, a list of the most common sources of pain include:

Less common possibilities

What tests are appropriate for occipital neuralgia ?

Like many other common health conditions (e.g. psychiatric conditions, migraine), occipital neuralgia is diagnosed solely from symptoms -- there are no blood or imaging studies that can prove that symptoms after a traumatic injury are "real" as opposed to "made up" in an attempt to obtain some benefit, perhaps compensation for an auto accident. Nevertheless, usually an astute clinician can draw a reasonable conclusion - - relief from blocks, and signs of severe pain (such as hypertension) during attacks often allow one to draw a reasonable inference.

An MRI or CT scan of the skull base is the most common test. A CT scan of the cervical spine is probably the most useful, because it visualizes the cervical facet joints. However, a reasonable case might also be made for MRI with soft tissue imaging of the neck, after trauma, looking for objective evidence of damage.

Vascular imaging may be done to look for carotid or vertebral dissection or vascular compression. This is extremely unlikely however and we don't recommend vascular imaging as a routine investigation.

How is occipital neuralgia treated ?

Occipital neuralgia can be extremely painful, and there are several treatment approaches. In general nerve blocks are used. Medications are usually not helpful for occipital neuralgia, but when ON is combined with migraine (which is common), then it makes sense to treat both.  (Sahai-Srivastava et al, 2011).

Blocks are injections of medication intended to temporarily deaden pain nerves. They are ordinarily done by anesthesiologists in a pain clinic, or neurologists in a headache clinic. An example is shown above. For occipital neuralgia, if the site of injury is the nerve itself such as when the nerve is bruised on the headrest of a car, the nerves should be blocked. The nerves have a fairly long course and several papers have been written concerning the optimal location to block (e.g. Natsis et al, 2006).

If the site of injury is one of the upper cervical nerve roots, then a more complex C2 cervical nerve block may need to be used.  This generally requires X-ray control.

If a block works temporarily, it usually wears off as the anesthetic effect stops. To obtain a more lasting effect, a more permanent procedure is to damage the nerve. Here, partial nerve injury could make the nerve even more irritable, and complete nerve destruction could lead to denervation pain.

If the occipital nerve block doesn't work, it is likely that the pain is coming from somewhere else. We have encountered patients with cervical facet disease who have pain resembling ON. As the cervical facet nerve is closer to the spinal cord than the occipital nerve, blocking the occipital nerve leaves cervical facet pain untouched. Similarly, an injury to the occipital nerves close to the spinal cord prior to emerging into the skull would be untouched by a peripheral occipital nerve block.

Occipital Nerve leads
Xray showing leads for occipital nerve stimulator.

Durable treatments of occipital neuralgia

As a general comment, these all involve doing something fairly long lasting -- usually damaging the occipital nerve.

At the present writing (2015), none of these methods seem entirely satisfactory, but decompression surgery and RFGN (done very cautiously) would seem to us most suitable right now. Treatments appear to be in very slow evolution. We find it puzzling that section of the occipital nerve, through RFGN or just rhizotomy is not done more often. As patients in litigation often seem to have symptoms that can persist in spite of reasonable treatments, it is possible that there is some interaction between the often litigious context of ON and the current difficulties with treatments. In other words, it is more difficult to prove that a treatment works in litigating patient populations that are resistant to reporting improvement. There are also formidable barriers to pain physicians to being compensated for treating occipital neuralgia. This likely also contributes to the difficult treatment situation for ON.

Oral medications for nerve pain

Aspirin or acetaminophen, nonsteroidal analgesics such as torodol, and narcotics are frequently used for neuralgia. Usually non-narcotic pain killers are not strong enough to control neuralgia pain, but they are worth a try anyway. Narcotic medications are highly addictive and there is usually an attempt to use other medications first.

Topical medications for nerve pain

In general, topical treatment for nerve pain is a good idea. It avoids many side effects, and avoids addiction.

Anticonvulsants used for pain.

These are commonly used for trigeminal neuralgia. Tegretol (carbamazepine), Dilantin (phenytoin), and Neurontin (gabapentin) are the most commonly used drugs (Robotham et al, 1998). The author of this review often uses Trileptal (oxcarbamazine). They are given in doses similar to used for epilepsy, but more leeway is given to the patient in adjusting the dose up and down, depending on the amount of activity of the neuralgia. Sodium Valproate has also been used for this purpose.

Regarding oxcarbazepine (Trileptal), although it is not FDA approved for this indication, it behaves similarly to carbamazepine. Adjunctive agents may be used in this situation. These include baclofen and amitryptyline (see following).

Antidepressants used for pain.

These are mainly used for post-herpetic neuralgia rather than ON. Amitriptyline is the most commonly used medication. Nortryptyline, desipramine and others can also be used. These medications have substantial side effects (e.g. sedation, dry mouth, weight gain). Some authors claim that amitriptyline should be started within 3-6 months of onset of shingles to get optimal relief (Bowsher, 1994). SNRI type antidepressants such as Cymbalta are used for neuropathic pain. It has been suggested that for this use, beta-blockers should be avoided (Yalcin et al, 2009). Another SNRI antidepressant, venlafaxine, is a very good drug for migraine.

Case example of treated occipital neuralgia:

A middle age woman experienced an automobile accident, and thereafter developed severe headaches with pain behind her right ear, nose bleeds, and loss of smell and taste.  There was tenderness and wincing on palpation of the area behind the right ear. A tentative diagnosis of Eagles syndrome was proposed, but X-rays did not bear this out.  Diagnostic blocks of the occipital nerve abolished the pain.  She subsequently had RF-ganglioneurectomy, with complete relief of headache for 6 months.

Although we presented a successful case here, practically speaking, lack of success is far more common.



Copyright March 20, 2017 , Timothy C. Hain, M.D. All rights reserved. Last saved on March 20, 2017